A multi-kinase inhibitor
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SB-1317

Item No. 26817

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
14-methyl-20-oxa-5,7,14,27-tetraazatetracyclo[19.3.1.12,6.18,12]heptacosa-1(25),2,4,6(27),8,10,12(26),16,21,23-decaene
CAS Number
937270-47-8
Synonyms
  • TG02
  • Zotiraciclib
Molecular Formula
C23H24N4O
Formula Weight
372.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: slightly solubleDMSO: 30 mg/ml
λmax
282 nm
SMILES
CN(CC1=CC=CC(/N=C2N=CC=C3N/2)=C1)C/C=C/CCOC4=CC=CC3=C4
InChi Code
InChI=1S/C23H24N4O/c1-27-13-3-2-4-14-28-21-10-6-8-19(16-21)22-11-12-24-23(26-22)25-20-9-5-7-18(15-20)17-27/h2-3,5-12,15-16H,4,13-14,17H2,1H3,(H,24,25,26)/b3-2+
InChi Key
VXBAJLGYBMTJCY-NSCUHMNNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    SB-1317 is a multi-kinase inhibitor.1 It inhibits Cdk1, -2, -3, -5, and -9 (IC50s = 3-9 nM), as well as JAK family kinases (IC50s = 14-59 nM), wild-type and mutant FLT3s (IC50s = 19-27 nM), and Src family kinases (IC50s = 11-15 nM). SB-1317 inhibits proliferation in a panel of 12 liquid and six solid tumor cell lines (mean IC50 = 0.19 µM). It induces cell cycle arrest at the G1 phase and apoptosis in MV4-11 acute myeloid leukemia (AML) cells. SB-1317 (10, 20, and 40 mg/kg) reduces tumor volume and increases survival in an MV4-11 mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Goh, K.C., Novotny-Diermayr, V., Hart, S., et al. TG02, a novel oral multi-kinase inhibitor of CDKs, JAK2 and FLT3 with potent anti-leukemic properties. Leukemia 26(2), 236-243 (2012).